Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Disorders of Erythrocytes

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

Translation

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...

Translation

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A novel US-based grading system for disease severity in sickle cell disease: the Sickle Cell Outcome Grading System (SCOGS).

The Lancet. Haematology·2026

Same author

Many uncertainties remain in the long-term care of sickle cell disease-pulmonary hypertension.

American journal of respiratory and critical care medicine·2026

Same author

Cure Sickle Cell Initiative recommendations on common data elements for sickle cell disease gene therapy trials.

Blood advances·2026

Same author

Gene Therapy for Sickle Cell Disease: Practice Recommendations from the American Society for Transplantation and Cellular Therapy and the International Society for Cell & Gene Therapy.

Transplantation and cellular therapy·2026

Same author

Cystic fibrosis and sickle cell disease associated with nonadministration of VTE prophylaxis in hospitalized adults.

Blood advances·2026

Same author

Sickle cell visualization in vivo in humans: microvascular occlusion formation and hemorheological indices.

Blood advances·2026

Same journal

The Role of Telemedicine on Interhospital Transfer Outcomes : A Systematic Review.

Annals of internal medicine·2026

Same journal

Prolonged Short Sleep and Its Effect on Body Weight and Composition : A Pooled Analysis of Randomized Trials.

Annals of internal medicine·2026

Same journal

In AF, LAAC was noninferior to NOAC therapy for a composite efficacy outcome and reduced non-procedure-related bleeding at 3 y.

Annals of internal medicine·2026

Same journal

How AI is affecting medical journals.

Annals of internal medicine·2026

Same journal

In adults with COPD, the BLISS score predicted risk for acute respiratory hospital admission at 2 y.

Annals of internal medicine·2026

Same journal

In AF at risk for stroke and bleeding, LAAC was not noninferior to medical therapy for a composite of thromboembolic and safety events.

Annals of internal medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 22, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Sickle Cell Disease.

Lydia H Pecker¹, Sophie Lanzkron¹

¹Johns Hopkins University School of Medicine, Baltimore, Maryland (L.H.P., S.L.).

Annals of Internal Medicine

|January 11, 2021

Summary

This summary is machine-generated.

Sickle cell disease (SCD) management is evolving, with hydroxyurea as primary therapy and new treatments like bone marrow transplant and gene editing offering potential cures for this complex hemoglobinopathy.

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

Related Experiment Videos

Last Updated: Nov 22, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

Area of Science:

Hematology
Genetics

Background:

Sickle cell disease (SCD) is a group of hemoglobinopathies caused by β-globin gene mutations, leading to hemoglobin S production.
SCD is linked to hemolytic anemia, chronic organ damage, and reduced lifespan.
A growing adult SCD population presents complex comorbidities and care challenges.

Purpose of the Study:

To review the diagnosis of sickle cell disease.
To outline common acute and chronic clinical manifestations.
To discuss best practices for managing sickle cell disease.

Main Methods:

Literature review of sickle cell disease diagnosis, manifestations, and management.
Analysis of current therapeutic approaches, including hydroxyurea, bone marrow transplant, and gene editing.

Main Results:

Hydroxyurea remains the primary therapy for sickle cell disease.
Advances in understanding pathophysiology have spurred novel treatment development.
Bone marrow transplant and gene editing show promise for curative outcomes in select patients.

Conclusions:

Effective management of sickle cell disease requires a comprehensive approach addressing diagnosis, manifestations, and evolving therapies.
The increasing adult SCD population necessitates specialized care and further research.
Emerging treatments offer hope for improved patient outcomes and potential cures.