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Cardiovascular disease in patients with COVID-19: evidence from cardiovascular pathology to treatment

Jinwen Luo1,2, Xiao Zhu2, Jie Jian3

  • 1The Department of Cardio-thoracic Surgery, Hunan Children's Hospital, Changsha 410007, China.

Acta Biochimica Et Biophysica Sinica
|January 11, 2021
PubMed

Insights

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic causes significant cardiovascular complications. Understanding these COVID-19-related cardiac issues is crucial for developing effective treatments.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
  • Cardiovascular disease is a major comorbidity linked to COVID-19 severity.
  • SARS-CoV-2 infection can lead to various cardiac complications.

Purpose of the Study:

  • To review recent advancements in understanding COVID-19's cardiovascular effects.
  • To describe the mechanisms behind SARS-CoV-2-induced cardiovascular injury.
  • To highlight the need for research into potential drug targets.

Main Methods:

  • This is a review article.
  • It synthesizes current research on COVID-19 and cardiovascular complications.
  • The review focuses on the underlying mechanisms of cardiac injury.

Main Results:

  • SARS-CoV-2 infection is associated with acute myocardial injury, myocarditis, heart failure, arrhythmias, myocardial infarction, cardiogenic shock, Takotsubo cardiomyopathy, and coagulation abnormalities.
  • The virus can directly or indirectly impact the cardiovascular system.
  • The precise mechanisms of these complications require further intensive research.

Conclusions:

  • COVID-19 poses significant risks to the cardiovascular system.
  • Elucidating the mechanisms of SARS-CoV-2-associated cardiovascular injury is critical.
  • Further research is essential for effective prevention and treatment strategies.

Keywords:
COVID-19SARS-CoV-2cardiovascular diseasecardiovascular injurytreatment

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