Soluble DC-SIGN isoforms: Ligands with unknown functions - A mini-review
Lailah Horácio Sales Pereira1, Amanda do Carmo Alves2, Jaqueline Maria Siqueira Ferreira3
1Laboratório de Biologia Molecular, Universidade Federal de São João Del Rei (UFSJ), Divinopolis, Minas Gerais, Brazil; Laboratório de Virologia, Universidade Federal de São João Del Rei (UFSJ), Divinopolis, Minas Gerais, Brazil.
Abstract:
The present study aimed to perform a mini-review of the complete soluble isoforms of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (sDC-SIGN), their functions, and their correlation with diseases. The present review reveals the lack of studies regarding these soluble isoforms and poor understanding of the importance of the topic, considering the concordant findings on the relevant influence of sDC-SIGN in the viral and bacterial infection process, in addition to its possible use as a cancer marker.
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