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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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The conversion of alkenes to macromolecules called polymers is a reaction of high commercial importance. The structure of the polymer is defined by a repeating unit, while the terminal groups are considered insignificant. The average degree of polymerization represents the number of repeating units in the polymer molecule and is denoted by the subscript n.
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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
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Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing
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Enzymatically Degradable Polyester-Based Adhesives.

Yinfeng Shi1, Peiran Zhou2, Valérie Jérôme2

  • 1Macromolecular Chemistry II and Bayreuth Center for Colloids and Interfaces, and ‡Chair for Process Biotechnology, Universität Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany.

ACS Biomaterials Science & Engineering
|January 12, 2021
PubMed
Summary
This summary is machine-generated.

A novel synthetic adhesive mimics DOPA for strong, degradable bonding to tissues and metals. This biocompatible material shows promise as a medical glue due to its high adhesion and stability.

Keywords:
biodegradable adhesivecatecholradical polymerizationring-opening polymerization

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Adhesive Technology

Background:

  • Developing synthetic adhesives with biocompatibility and tunable degradation is crucial for medical applications.
  • Existing medical glues often lack sufficient adhesion strength, biocompatibility, or controlled degradability.

Purpose of the Study:

  • To design and synthesize an enzymatically degradable synthetic adhesive with strong adhesion to both soft tissues and metals.
  • To evaluate the adhesive properties, stability, and potential as a medical glue.

Main Methods:

  • A two-step synthesis involving radical copolymerization of 2-methylene-1,3-dioxepane (MDO), glycidyl methacrylate (GMA), and oligo(ethylene glycol) methacrylate (OEGMA).
  • Immobilization of a catechol group (DOPA mimetic) onto the GMA epoxy rings.
  • Cross-linking using Fe(acac)3 and evaluation of lap shear strength on porcine skin and aluminum.

Main Results:

  • The synthesized adhesive demonstrated high lap shear strength: 13.13 ± 1.74 kPa on porcine skin and 218.4 ± 16.0 kPa on aluminum.
  • The adhesive exhibited good stability in pH 7 PBS buffer at 37 °C for over a week.
  • Fe(acac)3 was identified as the most effective cross-linking agent.

Conclusions:

  • The developed DOPA-mimetic adhesive offers strong, stable adhesion to diverse substrates.
  • Its enzymatic degradability and low toxicity make it a promising candidate for medical glue applications.
  • The simple two-step synthesis facilitates potential scalability.