Inkjet Printing-Based Patchable Multilayered Biomolecule-Containing Nanofilms for Biomedical Applications

Thin films including biocompatible polymers and biological materials as building blocks can be produced with a variety of critical film characteristics, including various materials, thicknesses, roughnesses, amounts of compound released, and release rates for biomedical purposes. We developed a multilayer fabrication system via high-throughput layer-by-layer (LbL) assembly of a nanofilm with inkjet printing to facilitate practical biomedical applications. Our system was used to generate biomolecule (ovalbumin and basic fibroblast growth factor)-containing printed LbL films. This is the first demonstration of the clinical benefits of nanofilm-type nanobiomaterials based on molecular organization, suggesting that novel therapeutic human skin patches could be realized without the need for conventional surgical practices.