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Related Experiment Videos

Development of the human sclera. A morphological study.

K Sellheyer1, M Spitznas

  • 1Universitäts-Augenklinik, Bonn, Federal Republic of Germany.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 1, 1988
PubMed
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Human scleral development progresses from front to back and inside out, with cellular changes starting around week 7.2. Collagen fibrils increase in diameter, and elastic microfibrils appear during early fetal development.

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Histology

Background:

  • The sclera, the protective outer layer of the eye, undergoes significant development during human gestation.
  • Understanding scleral differentiation is crucial for comprehending eye development and potential congenital abnormalities.

Purpose of the Study:

  • To investigate the spatiotemporal differentiation of the human sclera during embryonic and fetal development.
  • To characterize the cellular and ultrastructural changes occurring in the sclera from 6.4 to 24.0 weeks of gestation.

Main Methods:

  • Light and electron microscopy were employed to examine scleral tissue.
  • Human embryonic and fetal samples, ranging from 6.4 to 24.0 weeks of gestation, were analyzed.

Main Results:

Related Experiment Videos

  • Scleral differentiation follows an anteroposterior and inside-out developmental route.
  • Cytological maturation, including changes in endoplasmic reticulum and Golgi complex, begins anteriorly around 7.2 weeks.
  • Glycogen and lipid droplet accumulation starts in the inner scleral layers and progresses outwards.
  • Collagen fibril diameter increases significantly, and elastic microfibrils appear by 7.2 weeks, with distinct elastic deposits noted from 18 weeks.

Conclusions:

  • The human sclera differentiates in a coordinated manner, characterized by specific temporal and spatial cellular events.
  • The study provides detailed insights into the ultrastructural development of the sclera, including collagen and elastic fiber formation.
  • These findings contribute to our understanding of normal ocular development and may inform research on scleral pathologies.