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Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
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Urogenital Schistosomiasis-History, Pathogenesis, and Bladder Cancer
Lúcio Lara Santos1,2,3, Júlio Santos3, Maria João Gouveia4,5
1Experimental Pathology and Therapeutics, Research Centre, Portuguese Oncology Institute-Porto (IPO-Porto), 4200-072 Porto, Portugal.
Journal of Clinical Medicine
|January 12, 2021
Summary
Schistosomiasis, particularly Schistosoma haematobium infection, causes significant morbidity and mortality worldwide, leading to bladder cancer. Understanding host-parasite interactions is crucial for developing new treatments and prevention strategies.
Area of Science:
- Parasitology
- Oncology
- Epidemiology
Background:
- Schistosomiasis is a major global helminthiasis, with Schistosoma haematobium prevalent in Africa.
- S. haematobium infection is linked to urothelial and squamous cell carcinoma of the urinary bladder.
- Female genital schistosomiasis causes infertility and increases HIV transmission risk.
Purpose of the Study:
- To provide a historical overview of schistosomiasis.
- To review infection-associated pathologies.
- To explore host-parasite interactions in schistosomiasis-associated carcinogenesis.
Main Methods:
- Literature review of schistosomiasis pathologies.
- Analysis of studies on host-parasite interactions.
- Historical perspective on schistosomiasis research.
Main Results:
- Schistosoma haematobium infection is a known carcinogen, particularly for bladder cancer.
- Female genital schistosomiasis has significant reproductive health implications.
- Emerging outbreaks highlight the need for vigilance in non-endemic areas.
Conclusions:
- Further research into host-parasite interactions is essential to understand schistosomiasis-associated carcinogenesis.
- Schistosomiasis poses a significant public health threat requiring continued attention.
- Understanding these mechanisms can lead to novel therapeutic targets.
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