Related Experiment Video
Updated: Nov 21, 2025

07:04
Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
822
Immune-Checkpoint Inhibitors in B-Cell Lymphoma
Marc Armengol1, Juliana Carvalho Santos1, Miranda Fernández-Serrano1
1Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Spain.
Cancers
|January 12, 2021
Summary
Immune-checkpoint inhibitors targeting CTLA-4 and PD-1 have revolutionized cancer treatment. This review explores their advances and future potential in B-cell lymphoma, considering combination therapies.
Area of Science:
- Oncology
- Immunology
- Hematology
Background:
- Immunotherapy, particularly immune-checkpoint inhibitors, has transformed cancer treatment.
- Targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) pathways has shown success in solid tumors.
- Lymphomas, including Hodgkin and non-Hodgkin lymphoma, present unique interactions with the immune system, necessitating tailored therapeutic strategies.
Purpose of the Study:
- To review current advancements in immune-checkpoint blockade therapies for B-cell lymphoma.
- To project the future evolution of immune-checkpoint inhibitors in lymphoma treatment.
- To analyze preclinical and clinical strategies for enhancing immune-checkpoint inhibitor efficacy in lymphoma.
Main Methods:
- Review of current literature on immune-checkpoint inhibitors in B-cell lymphoma.
- Analysis of preclinical and clinical trial data.
- Exploration of combination therapy approaches.
Main Results:
- Immune-checkpoint inhibitors targeting CTLA-4 and PD-1 show therapeutic activity in lymphoma.
- Lessons from solid tumors may not fully translate to lymphoid malignancies due to differing antitumor response mechanisms.
- Understanding subtype-specific mechanisms is crucial for optimizing treatment.
Conclusions:
- Immune-checkpoint blockade is a promising avenue for B-cell lymphoma treatment.
- Combination strategies involving chemotherapy, biological agents, or other immunotherapies are under investigation.
- Further research is needed to elucidate lymphoma subtype-specific responses and optimize therapeutic outcomes.
Related Concept Videos
Tumor Immunotherapy
871
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
871
The Intrinsic Apoptotic Pathway
7.5K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
7.5K
Inhibition of Cdk Activity
5.3K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.3K
B Cell Activation and Differentiation
15.2K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.2K
Targeted Cancer Therapies
8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.1K

