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Hyperbaric Oxygen Therapy and A-PRF Pre-Treated Implants in Severe Periodontitis: A Case Report
Tommaso Antonio Giacon1, Franco Giancola2, Matteo Paganini1
1Department of Biomedical Sciences, Environmental and Respiratory Physiology, University of Padova, Via Marzolo 3, 35131 Padova, Italy.
International Journal of Environmental Research and Public Health
|January 12, 2021
Summary
This case study shows advanced platelet-rich fibrin-enriched zirconia implants combined with hyperbaric oxygen therapy (HBOT) successfully treated severe periodontitis. HBOT promoted bone regeneration and implant integration, offering a potential new treatment approach.
Area of Science:
- Dental Implantology
- Periodontology
- Regenerative Medicine
Background:
- Dental implants are optimal for tooth replacement in periodontitis patients.
- Acute periodontitis and infection are contraindications for immediate implants.
Observation:
- A 51-year-old female patient with severe periodontitis underwent treatment with a-PRF-enriched zirconia implants.
- The patient received hyperbaric oxygen therapy (HBOT) before and after the implantation procedure.
- HBOT was administered to enhance bone regeneration, promote implant integration, and provide an antiseptic effect.
Findings:
- The combined therapy of a-PRF-enriched zirconia implants and HBOT demonstrated significant bone regeneration and successful implant integration.
- The patient's periodontal disease healed completely within 14 months post-implantation.
- Implants were well-established and stable after six months.
Implications:
- This case suggests a potential new indication for hyperbaric oxygen therapy (HBOT) in managing severe periodontitis and improving dental implant outcomes.
- The findings support the use of a-PRF-enriched zirconia implants in complex periodontal cases.
- Further clinical research is warranted to validate HBOT as an adjunct therapy for periodontitis and dental implantology.

