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Effects of In-Hospital Exercise on Frailty in Patients with Hepatocellular Carcinoma
Jin Tsuchihashi1, Shunji Koya2, Keisuke Hirota2
1Division of Rehabilitation, Fukui-ken Saiseikai Hospital, Fukui 918-8503, Japan.
In-hospital exercise significantly improved frailty in patients with hepatocellular carcinoma (HCC). This intervention may enhance physical function for HCC patients during hospitalization.
Area of Science:
- Oncology
- Geriatrics
- Physical Therapy
Background:
- Frailty, often linked to physical inactivity, negatively impacts survival in hepatocellular carcinoma (HCC) patients.
- Assessing and improving frailty is crucial for managing HCC and enhancing patient outcomes.
Purpose of the Study:
- To investigate the impact of in-hospital exercise interventions on frailty levels in patients diagnosed with hepatocellular carcinoma (HCC).
Main Methods:
- A multi-center observational study comparing an exercise group (aerobic and resistance training) with a non-exercise group.
- Frailty was quantified using the liver frailty index (LFI), with analyses including multivariate and decision-tree approaches, and propensity score matching.
Main Results:
- The exercise group showed a significant improvement in LFI compared to the non-exercise group (ΔLFI -0.17 vs. -0.02, p = 0.0119).
- In-hospital exercise was identified as an independent factor for LFI improvement, alongside female gender, in multivariate and decision-tree analyses.
Conclusions:
- In-hospital exercise interventions demonstrably improve frailty in patients with hepatocellular carcinoma (HCC).
- Implementing exercise programs during hospitalization could be a beneficial strategy for enhancing physical function in HCC patients.
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