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Pulse rhythm

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...

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Related Experiment Video

Updated: Nov 21, 2025

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

Copeptin reliably reflects longitudinal right ventricular function.

Melissa Harbrücker¹, Michèle Natale¹, Seung-Hyun Kim¹

¹First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.

Annals of Clinical Biochemistry

|January 12, 2021

Summary

This summary is machine-generated.

The novel biomarker copeptin reflects right heart function, offering a new tool for assessing patients with heart failure. This finding is comparable to NT-proBNP in evaluating longitudinal right heart function.

Keywords:

Copeptin diagnosis right heart failure right heart function right ventricle

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Last Updated: Nov 21, 2025

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Published on: February 3, 2014

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Published on: December 13, 2019

Area of Science:

Cardiology
Biomarker Research
Echocardiography

Background:

Limited data exists on novel biomarkers for right ventricular dysfunction.
Normal right heart function is crucial for heart failure patient prognosis.
This study explores copeptin's association with right heart function versus NT-proBNP.

Purpose of the Study:

To investigate the association between the novel biomarker copeptin and right heart function.
To compare copeptin's efficacy with NT-proBNP in assessing right ventricular function.

Main Methods:

Prospective enrollment of patients undergoing routine echocardiography.
Right ventricular function assessed by tricuspid annular plane systolic excursion (TAPSE) and other parameters.
Exclusion of patients with LVEF < 50% or moderate/severe valvular heart disease; biomarker analysis within 72 hours of echocardiography.

Main Results:

Copeptin levels significantly increased with decreasing TAPSE values (P=0.001).
Copeptin effectively discriminated decreased right heart function (TAPSE < 18 mm) with an AUC of 0.793.
Copeptin was independently associated with TAPSE in multivariable regression (P=0.0001) and associated with severe dysfunction (OR=0.94, P=0.001).

Conclusions:

The novel biomarker copeptin reflects longitudinal right heart function.
Copeptin serves as a valuable marker in assessing right ventricular function via echocardiography.
Findings suggest copeptin's potential utility in managing heart failure patients with right ventricular dysfunction.