Polyurethane Versus Chitosan-Based Polymers Nasal Packs After Functional Endoscopic Sinus Surgery: A Prospective...

Area of Science:

• Otolaryngology
• Biomaterials Science
• Surgical Innovation

Background:

• Nasal packing is crucial after sinonasal surgery for drainage, ventilation, and complication prevention.
• Various materials are used, necessitating comparative studies for optimal clinical outcomes.

Purpose of the Study:

• To compare the clinical efficacy and safety of Chitosan-based polymers (CBP) versus synthetic polyurethane nasal packs.
• Evaluate outcomes including material remnants, crusting, bleeding, infection, and patient satisfaction post-functional endoscopic sinus surgery.

Main Methods:

• A randomized study involving 50 patients with chronic rhinosinusitis with nasal polyposis.
• Bilateral surgical cavities were packed with either CBP or synthetic polyurethane, with outcomes assessed over 12 weeks.

Main Results:

• CBP packs demonstrated a statistically significant advantage in reducing material remnants, crusting, and bleeding within the first two weeks.
• No significant differences were observed between the groups regarding granulations, adhesions, or infection over 12 weeks.
• Adverse effects like odor and rhinorrhea were reported with CBP but were not statistically significant.

Conclusions:

• Both synthetic polyurethane and CBP nasal packs are safe and effective for mucosal healing and bleeding control.
• CBP offers superior short-term benefits in the initial two weeks post-surgery.
• Long-term outcomes and patient satisfaction are comparable between the two absorbable nasal packing materials.