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Peripheral Neuropathy in Wild-Type Amyloidosis: The More You Look, the More You Will Find
1Department of Neurology and Neurosurgery, Montreal Neurological Hospital, McGill University, Montreal, Quebec, Canada.
Abstract
No abstract available in PubMed .
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Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
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