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Updated: Nov 21, 2025

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
[Peritoneal dialysis catheter sterilization by urokinase administration in case of relapsing peritonitis: About four
Céline Bouery1, Latifa Azeroual2, Gilles Hufnagel3
1Département de néphrologie, CHU Bichat-Claude Bernard, 75000 Paris, France; Département de néphrologie, Hôpital Saint-Georges Ajaltoum, Beyrouth, Liban; Département de néphrologie, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, Institut Recherche Expérimentale et Clinique, avenue Hippocrate 10, 1200 Bruxelles, Belgique.
Abstract:
The presence of a biofilm within the peritoneal dialysis catheter where bacteria are encapsulated, protected from the action of antibiotics and insidiously liberated within the dialysate, best explains the relapse of the infectious peritonitis, when antibiotics are withdrawn. We here report a serie of four clinical cases in whom the administration of urokinase within the peritoneal catheter in addition to the current antibiotherapy, has cured relapsing peritonitis due to Staphylococcus epidermidis in two cases, Acinetobacterjohnsonii in one case and Staphylococcus haemolyticus in one case, respectively. This approach, safe and easy, allowed the infection eradication and did prevent a catheter removal and a potential transfer of the patients to hemodialysis.
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