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Updated: Nov 21, 2025

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
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Perineuronal nets stabilize the grid cell network

Ane Charlotte Christensen1,2,3, Kristian Kinden Lensjø2,3, Mikkel Elle Lepperød1,2,3

  • 1Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Nature Communications
|January 12, 2021
PubMed
Summary

Perineuronal nets (PNNs) stabilize grid cell networks essential for spatial memory and navigation. Their removal disrupts stable spatial representations and impairs navigation in novel environments.

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