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Updated: Nov 21, 2025

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
Metabolic Messengers: glucagon-like peptide 1
Fiona M Gribble1, Frank Reimann2
1Wellcome Trust MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. fmg23@cam.ac.uk.
Abstract:
Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis through actions on insulin secretion, food intake and gut motility. GLP-1 forms the basis for a variety of current drugs for the treatment of type 2 diabetes and obesity, as well as new agents currently being developed. Here, we provide a concise overview of the core physiology of GLP-1 secretion and action, and the role of the peptide in human health, disease and therapeutics.
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