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Variable Presentation of COVID-19 in Pediatric Patients

Richard L Crawford1, Elijah H Bolin, Parthak Prodhan

  • 1From the Department of Pediatrics, Section of Cardiology, University of Arkansas for Medical Sciences Little Rock, Arkansas.

The Pediatric Infectious Disease Journal
|January 12, 2021
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection presents with two distinct clinical patterns. These differing presentations suggest varied disease courses and potential long-term outcomes in pediatric patients.

Area of Science:

  • Pediatric infectious diseases
  • Viral pathogenesis
  • Immunology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19).
  • A subset of pediatric COVID-19 cases manifests as multisystem inflammatory syndrome in children (MIS-C).

Observation:

  • This study details clinical experiences with MIS-C in children.
  • Two distinct clinical presentations of MIS-C were identified.

Findings:

  • The identified MIS-C presentations exhibit different clinical trajectories.
  • These distinct clinical courses may correlate with varying long-term prognoses.

Implications:

  • Understanding these distinct MIS-C presentations is crucial for accurate diagnosis and management.
  • Further research into the differing long-term outcomes of MIS-C is warranted.
  • This classification aids in predicting patient trajectories and informing therapeutic strategies.

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