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Modified improvised pre-embedding method for core needle biopsies: A clinicopathologic study.

Nikita Sunny1, Anupa Thomas1, Suraj Manjunath2

  • 1Department of Pathology, St. John's Medical College and Hospital, Bangalore, Karnataka, India.

Indian Journal of Pathology & Microbiology
|January 12, 2021
PubMed
Summary

A new pre-embedding method using polyurethane foam and coloring inks improves core needle biopsy (CNB) processing. This cost-effective technique yields intact cores, enhancing diagnostic accuracy and efficiency in surgical pathology.

Keywords:
Core needle biopsiespolyurethane meshpre-embedding histologic techniquetissue coloring inks

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Area of Science:

  • Surgical Pathology
  • Histotechnology

Background:

  • Core needle biopsy (CNB) is crucial for tissue diagnosis and treatment selection.
  • Current CNB processing lacks standardized guidelines, leading to variable laboratory practices.
  • A user-friendly, cost-effective pre-embedding method is needed to ensure intact CNB cores.

Purpose of the Study:

  • To compare the diagnostic outcomes of CNBs processed via a conventional method versus a modified pre-embedded protocol.
  • To evaluate the effectiveness of a novel pre-embedding technique for CNB specimens over a two-year period.

Main Methods:

  • CNBs from solid organ lesions (SOL) were processed using either the conventional free-floating formalin method (control) or a modified pre-embedding technique with polyurethane foam meshes and coloring inks (test).
  • Specimens were assessed for core intactness, tissue processing quality, ease of embedding, and ease of section cutting.
  • Statistical analysis was performed on the collected data.

Main Results:

  • CNBs processed with the modified pre-embedding method demonstrated superior intactness, linearity, and alignment compared to the control group.
  • The number of blocks and sections required was reduced by 25% when processing four CNBs within a single block using the new method.
  • The modified technique proved more economical and efficient.

Conclusions:

  • The pre-embedding method utilizing polyurethane foam and coloring inks offers superior results compared to conventional free-floating CNB processing.
  • This technique is economical, user-friendly, and can be implemented at the bedside by surgeons.
  • The improved processing enhances diagnostic yield and efficiency in histopathology.