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Related Concept Videos

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...
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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
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The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production takes place. A nephron has two main components: a renal corpuscle and a renal tubule. Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent...
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Updated: Nov 21, 2025

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Lysosome function in glomerular health and disease.

Catherine Meyer-Schwesinger1

  • 1Institute for Cellular and Integrative Physiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany. c.meyer-schwesinger@uke.de.

Cell and Tissue Research
|January 12, 2021
PubMed
Summary

Lysosomes are key cellular hubs regulating metabolism and immunity. This review explores their function in kidney glomerular cells, impacting health and disease.

Keywords:
Crescentic glomerulonephritisDiabetic nephropathyFocal segmental glomerulosclerosisGlomerular endothelial cellGlomerulusLysosomal storage disorderLysosomeMembranous nephropathyMesangial cellPodocyte

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Area of Science:

  • Cell Biology
  • Renal Physiology
  • Molecular Medicine

Background:

  • Lysosomes are central organelles in cellular trafficking pathways, including endocytosis, phagocytosis, and autophagy.
  • They degrade diverse cargo and act as signaling hubs for cellular metabolism, immune response, and inter-cellular communication.
  • Lysosomes play critical roles in membrane repair and maintaining cellular homeostasis.

Purpose of the Study:

  • To review general lysosome function.
  • To discuss the implications of lysosome function in renal glomerular cells in health and disease.
  • To highlight the role of lysosomes in lysosomal storage diseases and non-genetic glomerular injuries.

Main Methods:

  • This is a review article, synthesizing existing knowledge.
  • It involves a comprehensive literature search and analysis of current research.
  • Focuses on integrating findings related to lysosome biology and kidney pathology.

Main Results:

  • Lysosomes are crucial for degrading cellular waste and pathogens within glomerular cells.
  • Dysfunctional lysosomes contribute to lysosomal storage diseases affecting the kidney.
  • Non-genetic glomerular injuries also involve aberrant lysosomal activity and signaling.

Conclusions:

  • Lysosomes are vital for glomerular cell function and kidney health.
  • Understanding lysosome biology offers therapeutic targets for kidney diseases.
  • Further research into lysosomal roles in renal pathology is warranted.