Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

3.0K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
3.0K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

15.0K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
15.0K
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

2.1K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
2.1K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

82
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
82
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

358
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
358
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

105
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
105

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scutellarin Alleviates Hepatic Steatosis by Autophagy-Mediated NCoR1/PPARα-Driven Fatty Acid β-Oxidation and Enhancing Peroxisome Biogenesis.

Phytotherapy research : PTR·2026
Same author

Deciphering IFN signaling in gastric cancer: A single-cell and bulk transcriptomic integration reveals CXCR4 as a key immunomodulator and prognostic determinant.

Translational oncology·2026
Same author

Gui Shen Wan ameliorates PCOS-like cellular phenotypes by suppressing TNF-α-mediated inflammation and restoring the PI3K/Akt signaling pathway.

Frontiers in immunology·2026
Same author

The HPCA1-VDAC3 module mediates the humidity adaptation trade-off by interfering with ROS homeostasis in Arabidopsis thaliana.

Journal of genetics and genomics = Yi chuan xue bao·2026
Same author

Homoplantaginin alleviates high glucose-induced vascular endothelial barrier dysfunction by regulating Yes-associated protein 1.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

The ESCRT component FYVE4 modulates salt-stress response by strengthening the SOS1-SOS2 interaction in Arabidopsis.

Plant communications·2025

Related Experiment Video

Updated: Nov 21, 2025

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
08:47

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells

Published on: May 1, 2020

3.3K

Hepatic metabolic regulation by nuclear factor E4BP4.

Zifeng Zhao1,2, Lei Yin2, Feihua Wu1

  • 1Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province, China.

Journal of Molecular Endocrinology
|January 12, 2021
PubMed
Summary

E4 promoter-binding protein 4 (E4BP4) is a key regulator of liver metabolism, impacting lipid, glucose, and bile processes. Targeting E4BP4 offers potential for treating metabolic disorders.

Keywords:
E4BP4glucoseinsulinlipidmetabolism

More Related Videos

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
08:14

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration

Published on: May 20, 2015

8.9K
Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
08:50

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

Published on: September 26, 2014

10.4K

Related Experiment Videos

Last Updated: Nov 21, 2025

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
08:47

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells

Published on: May 1, 2020

3.3K
Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
08:14

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration

Published on: May 20, 2015

8.9K
Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
08:50

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

Published on: September 26, 2014

10.4K

Area of Science:

  • Molecular Biology
  • Metabolic Research
  • Hepatology

Background:

  • E4 promoter-binding protein 4 (E4BP4) is a b-ZIP transcription repressor with established roles in immunity, circadian rhythms, and cancer.
  • Emerging evidence identifies E4BP4 as a significant regulator of metabolic processes across various tissues.
  • Hepatic E4BP4's involvement in metabolism is a recent and rapidly developing area of research.

Purpose of the Study:

  • To review the function and regulatory mechanisms of hepatic E4 promoter-binding protein 4 (E4BP4).
  • To explore E4BP4's role in maintaining lipid and glucose homeostasis within the liver.
  • To discuss E4BP4's influence on bile and xenobiotic metabolism and its therapeutic potential for metabolic disorders.

Main Methods:

  • Literature review of studies on E4 promoter-binding protein 4 (E4BP4) function in hepatic metabolism.
  • Analysis of research detailing E4BP4's molecular mechanisms in regulating metabolic pathways.
  • Identification and discussion of E4BP4-specific targets for therapeutic intervention.

Main Results:

  • Hepatic E4BP4 plays a crucial role in regulating lipid and glucose homeostasis.
  • E4BP4 influences bile acid metabolism and the processing of xenobiotics in the liver.
  • Specific molecular targets of E4BP4 involved in metabolic regulation have been identified.

Conclusions:

  • E4 promoter-binding protein 4 (E4BP4) is a critical regulator of hepatic metabolic functions.
  • Understanding E4BP4 mechanisms provides insights into preventing and treating metabolic diseases.
  • E4BP4 represents a promising therapeutic target for various metabolic disorders.