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The design of cyclometalated iridium(iii)-metformin complexes for hypoxic cancer treatment
Jing Yang1, Hao-Ji Fang, Qian Cao
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. caoqian3@mail.sysu.edu.cn cesmzw@mail.sysu.edu.cn.
Abstract:
Modulating the hypoxic microenvironment is the priority for tumor treatment. Cytometalated iridium(iii)-metformin conjugates were synthesized for treating hypoxic cancer cells for the first time, which alleviate hypoxia via mitochondria respiration inhibition, thus displaying 10-fold higher cytotoxicity, emerging anti-metastasis and anti-inflammatory activities than a metformin-free Ir(iii) complex and cisplatin against hypoxic cancer cells.
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