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Updated: Nov 21, 2025
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
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Clinically detectable structural abnormalities in pediatric-onset multiple sclerosis: A large-scale magnetic
Jacob Levman1, Avilash Das2, Allissa MacDonald3
1Department of Computer Science, St. Francis Xavier University, Antigonish, NS, Canada.
Summary
Structural brain abnormalities are common in pediatric multiple sclerosis (MS). This MRI study found reduced cortical thickness, particularly in the parahippocampal region, and other structural changes.
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Multiple Sclerosis (MS) involves neural demyelination.
- Structural Magnetic Resonance Imaging (MRI) offers soft tissue contrast for brain biomarker extraction.
Purpose of the Study:
- To analyze the clinical presentation of MS using large-scale MRI.
- To investigate regional cortical thickness, surface measurements, and volumes in MS patients.
Main Methods:
- Retrospective analysis of 370 T1 structural MRIs from 64 MS patients.
- Comparison with 993 MRIs from 988 neurotypical participants.
- Extraction of regional cortical thickness (average and standard deviation), surface area, curvature, and volumes.
Main Results:
- Significant reductions in average cortical thickness were observed regionally.
- The parahippocampal region showed the largest effect size for cortical thickness reduction.
- Group differences were noted in volume, surface area, and surface curvature.
Conclusions:
- Pediatric-onset MS presents with diverse structural abnormalities.
- Perirhinal cortex thickness abnormalities were identified, a novel finding.
