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Updated: Nov 21, 2025

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
Stromal WNTer Keeps the Tumor Cold and Drives Metastasis
Rene Jackstadt1, Jim C Norman2
1Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany; Division of Cancer Progression and Metastasis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Abstract:
Carcinoma-associated fibroblast (CAF) infiltration confers poor clinical outcomes in colorectal cancer (CRC) through mechanisms that are still unclear. In this issue of Developmental Cell, Kasashima et al. report that loss of PKCζ engenders a SOX2/SFRP2-positive CAF subpopulation that increases CRC aggressiveness by creating an immunosuppressed environment.
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