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Related Experiment Video

Updated: Nov 21, 2025

Planar and Three-Dimensional Printing of Conductive Inks
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Planar and Three-Dimensional Printing of Conductive Inks

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Precise Microscale Polymeric Networks through Piezoelectronic Inkjet Printing.

Benjamin R Spears1, Michael A Marin2, Anisse N Chaker2

  • 1Department of Chemistry and ‡Department of Chemical and Biomolecular Engineering, Vanderbilt University, 7665 Stevenson Center, Nashville, Tennessee 37235, United States.

ACS Biomaterials Science & Engineering
|January 13, 2021
PubMed
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This study introduces a facile technique using unique polymeric building blocks and inkjet printing to create precisely sized microsized hydrogel particles for drug delivery. These particles offer controlled morphology and hydrophilicity, enhancing their potential for carrying and releasing therapeutic cargo.

Area of Science:

  • Materials Science
  • Biotechnology
  • Chemical Engineering

Background:

  • Microsized particles are crucial for drug delivery systems like inhalants, implants, and vaccines.
  • Existing fabrication methods often lack control over particle size, morphology, and drug release kinetics.
  • There is a need for facile techniques to produce drug delivery particles with tunable properties.

Purpose of the Study:

  • To develop a facile fabrication technique for producing microsized hydrogel particles with controlled dimensions, morphology, and hydrophilicity.
  • To utilize unique polymeric building blocks and piezoelectric inkjet printing for precise particle fabrication.
  • To demonstrate the potential of these particles as advanced drug delivery candidates.

Main Methods:

  • Employed allyl-functionalized polycarbonates and poly(glycidol allylglycidyl ether)s with dithiol-PEG cross-linkers.
Keywords:
control of micrometer-sized particles and morphologieshydrophilic particlesink jet printingmicrosized particles

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  • Utilized piezoelectric inkjet printing for direct droplet deposition and subsequent UV-initiated thiol-ene click cross-linking.
  • Varied the ratio of polycarbonate and polyglycidol building blocks to modulate particle properties and printing solvents (DMSO or water).
  • Investigated polymer concentration and droplet volume to control particle size.

    • Main Results:

    • Successfully fabricated microsized hydrogel particles in controlled size ranges (18-12 μm, 12-8 μm, 1-2 μm).
    • Achieved modulated particle morphologies and hydrophilicity by adjusting the ratio of polycarbonate and polyglycidol building blocks.
    • Demonstrated a 20% reduction in particle size by decreasing polymer concentration, maintaining controlled dimensions.
    • Developed a lithography-free method for producing homogeneous microsized hydrogel particles.

    Conclusions:

    • A facile and versatile technique for preparing tunable microsized hydrogel particles has been established.
    • The combination of unique polymeric building blocks and inkjet printing offers precise control over particle characteristics.
    • These hydrogel particles show significant promise for diverse drug delivery applications, enabling controlled release of therapeutic agents.