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Cell Lines

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...

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Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

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Advanced Cell and Tissue Biomanufacturing.

Kaiming Ye¹, David L Kaplan², Gang Bao³

¹Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Watson School of Engineering and Applied Science, Binghamton University, State University of New York (SUNY), Binghamton, New York 13902, United States.

ACS Biomaterials Science & Engineering

|January 13, 2021

Summary

This summary is machine-generated.

Advanced biomanufacturing is an emerging field in biotechnology. This paper outlines key challenges and opportunities to advance biomanufacturing research and industry growth.

Keywords:

3D bioprinting biosystem integration cell advanced manufacturing systems biology tissue biofabrication

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Area of Science:

Biotechnology
Biomedical Engineering
Advanced Biomanufacturing

Background:

The field of advanced biomanufacturing is rapidly evolving.
Significant scientific and industrial progress has been observed in recent years.

Purpose of the Study:

To assess the current state of advanced biomanufacturing.
To identify future research, translational, and corporate opportunities.
To define paths for advancing the discipline in academic and industrial settings.

Main Methods:

A National Science Foundation-sponsored workshop convened experts to discuss the field.
Discussions focused on identifying barriers and opportunities in advanced biomanufacturing.
The position paper synthesizes workshop outcomes and expert recommendations.

Main Results:

Key needs include interdisciplinary integration, regulatory guidance, and infrastructure development.
Strategies for reliable systems integration are crucial for progress.
"Grand challenges" were identified to stimulate field advancement.

Conclusions:

Advanced biomanufacturing holds significant future impact for science and technology.
Collaboration networks and strategic initiatives are vital for growth.
Addressing identified challenges will accelerate the field's development.