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The Human Cutaneous Sensory Corpuscles: An Update.
Ramón Cobo1, Jorge García-Piqueras1,2, Juan Cobo3,4
1Departamento de Morfología y Biología Celular, Grupo SINPOS, Universidad de Oviedo, 33003 Oviedo, Spain.
Journal of Clinical Medicine
|January 13, 2021
Summary
Human skin sensory corpuscles, acting as low-threshold mechanoreceptors, are crucial for dermatological diagnosis. Understanding their structure and immunohistochemistry aids in diagnosing nerve involvement in various systemic and central nervous system diseases.
Area of Science:
- Dermatology
- Neuroscience
- Histology
Background:
- Human skin sensory corpuscles are specialized nerve endings functioning as low-threshold mechanoreceptors.
- They comprise mechanosensory axons and non-neuronal glial cells, enclosed by connective tissue.
- Pathologies are rare, but their structure is vital for dermatologists and pathologists.
Purpose of the Study:
- To update and summarize current knowledge on the immunohistochemistry of human sensory corpuscles.
- To provide essential information for dermatologists and skin pathologists regarding sensory corpuscle structure and function.
- To highlight the diagnostic utility of cutaneous sensory corpuscle biopsies in neurological and systemic diseases.
Main Methods:
- Review and synthesis of existing literature on sensory corpuscle structure and immunohistochemistry.
- Analysis of shared structural and protein compositions between sensory corpuscles and peripheral nerves.
- Emphasis on the role of immunohistochemistry in characterizing sensory corpuscle components.
Main Results:
- Sensory corpuscles are complex structures involving neural and glial elements, with varied morphologies.
- Immunohistochemical profiles are essential for understanding their cellular composition and function.
- Cutaneous biopsies of sensory corpuscles can reveal nerve involvement in systemic and central nervous system disorders.
Conclusions:
- Knowledge of sensory corpuscle immunohistochemistry is crucial for dermatologists and pathologists.
- Cutaneous biopsies offer a complementary diagnostic tool for assessing nerve involvement in various pathologies.
- This updated information aids in the diagnosis, monitoring, and treatment evaluation of related diseases.
Keywords:
Meissner corpusclesPacinian corpusclesRuffini corpuscleshumansensory corpusclesskin sensory innervationMore Related Videos
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