Pubertal induction in girls with Turner Syndrome
Tommaso Aversa1, Domenico Corica2, Giorgia Pepe2
1Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy - taversa@unime.it.
Minerva Endocrinology
|January 13, 2021
Summary
Pubertal induction for Turner Syndrome (TS) should start between 11-12 years with low-dose transdermal estradiol to preserve height. Treatment requires individualized monitoring for optimal outcomes in girls with this common sex chromosome aneuploidy.
Area of Science:
- Endocrinology
- Genetics
- Pediatrics
Background:
- Turner Syndrome (TS) is the most common female sex chromosome aneuploidy.
- Patients often present with hypergonadotropic hypogonadism due to gonadal dysgenesis.
- Optimal timing and methods for pubertal induction in TS remain debated.
Purpose of the Study:
- To review the latest updates on pubertal induction strategies for Turner Syndrome.
- To provide a practical, evidence-based approach for initiating puberty in TS patients.
Main Methods:
- Literature review of current data on pubertal induction in Turner Syndrome.
- Analysis of recommended starting age, hormone regimens, and progression protocols.
Main Results:
- Recommended initiation of pubertal induction between 11 and 12 years of age.
- Transdermal 17β-Estradiol (17β-E2) is suggested as a first-choice regimen for physiologic induction and height preservation.
- Incremental dose adjustments over 2-3 years and individualized progestin addition are advised.
Conclusions:
- Early, individualized pubertal induction is crucial for Turner Syndrome management.
- Transdermal estradiol offers a physiologic approach, with oral options for compliance issues.
- Further randomized trials are needed to determine optimal estrogen regimens for TS girls.
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