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Published on: March 26, 2018
Management of Descending Thoracic Aortic Diseases: Similarities and Differences Among Cardiovascular Guidelines
Konstantinos Spanos1,2, Petroula Nana1, Christian-Alexander Behrendt2
1Department of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Insights
Cardiovascular guidelines show agreement on managing thoracic aortic diseases, with thoracic endovascular aortic repair (TEVAR) often preferred for dissections and aneurysms. Further evidence is needed for complex pathologies.
Area of Science:
- Cardiovascular Medicine
- Thoracic Aortic Diseases
- Medical Guidelines
Background:
- Cardiovascular societies provide recommendations for managing thoracic aortic diseases.
- The increasing use of thoracic endovascular aortic repair (TEVAR) necessitates a review of its indications and limitations.
- Existing guidelines require assessment for consistency and areas needing further research.
Purpose of the Study:
- To systematically review and compare current cardiovascular society guidelines for thoracic aortic disease management.
- To identify similarities, differences, and controversial aspects in guideline recommendations.
- To highlight areas requiring further investigation and evidence generation.
Main Methods:
- Systematic review of guidelines from major cardiovascular societies.
- Searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (January 2009 - May 2020).
- Analyzed 5 selected guidelines (2010-2020) focusing on diagnosis, imaging, prevention, and management of various thoracic aortic pathologies.
Main Results:
- Significant overlap and agreement were found among the 5 reviewed guidelines.
- Thoracic endovascular aortic repair (TEVAR) is consistently recommended as a primary treatment for aortic dissection and aneurysm.
- Areas of controversy and 'gray zones' requiring further investigation were identified across different pathologies.
Conclusions:
- Current guidelines demonstrate substantial consensus on managing thoracic aortic diseases, particularly regarding TEVAR.
- Despite agreement, robust evidence is still lacking for several thoracic aortic pathologies and specific management strategies.
- Further research is crucial to address evidence gaps and refine future clinical recommendations.
Abstract:
Cardiovascular societies have developed recommendations regarding the management of thoracic aortic diseases. While improvements in treatment have been observed during the past decade in regard to patient selection, thoracic endovascular aortic repair (TEVAR) and associated techniques, and high-volume centralization, the broad expansion of TEVAR has raised considerations about its indications, appropriateness, limitations, and application. The aim of this systematic review was to assess the similarities and differences among current cardiovascular societies' guidelines for the management of thoracic aortic diseases. The MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched from January 2009 to May 2020. The initial search identified 990 articles. After exclusion of duplicate or inappropriate articles, the final analysis included 5 articles from cardiovascular societies published between 2010 and 2020. Selected controversial topics were analyzed, including diagnosis, imaging, spinal cord ischemia prevention, and management of the most important thoracic aortic pathologies. The analysis included data concerning the therapeutic approach in acute and chronic type B aortic dissection, penetrating aortic ulcer, intramural hematoma, thoracic aortic aneurysm, and traumatic aortic injury, as well a discussion of inflammatory aneurysms, aortitis, and genetic syndromes. The review presents consistent and controversial recommendations, as well as "gray zone" issues that need further investigation. There was significant overlap and agreement among the 5 societies regarding the management of thoracic aortic diseases. Especially in dissection and aneurysm management, TEVAR has established its role as the treatment of choice. However, robust evidence is still needed in many aspects of the management of thoracic aortic pathologies.
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