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Intracellular coupling modulates biflagellar synchrony.

Hanliang Guo1,2, Yi Man1, Kirsty Y Wan3

  • 1Aerospace & Mechanical Engineering, University of Southern California, Los Angeles, CA 90089, USA.

Journal of the Royal Society, Interface
|January 13, 2021
PubMed
Summary
This summary is machine-generated.

Cellular contractile fibers, not just water flow, actively control flagellar synchronization. Mathematical models show basal coupling alone can achieve various synchrony modes in Chlamydomonas reinhardtii.

Keywords:
Chlamydomonas reinhardtiiciliacoupled oscillatorscytoskeletonelastic filamentsmicrohydrodynamics

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Area of Science:

  • Cell Biology
  • Biophysics
  • Mathematical Modeling

Background:

  • Flagellar synchrony is crucial for cell motility.
  • Hydrodynamic coupling was the presumed mechanism for flagellar coordination.
  • Recent studies suggest internal cellular mechanisms, like contractile fibers, also play a role.

Purpose of the Study:

  • To investigate the role of basal coupling in flagellar synchronization.
  • To model flagellar coordination in Chlamydomonas reinhardtii.
  • To determine if internal basal coupling is sufficient for synchrony.

Main Methods:

  • Developed mathematical models of flagellar synchronization with decreasing complexity.
  • Simulated flagellar coordination under varying basal coupling strengths and flagellar activity levels.
  • Introduced a dimensionless ratio to predict synchrony modes.

Main Results:

  • Basal coupling alone can produce in-phase, anti-phase, and bistable synchrony.
  • A 'slip mode' was observed with differential flagellar activity, matching experimental data.
  • A predictive ratio of flagellar activity to basal coupling was identified.

Conclusions:

  • Internal basal coupling is a sufficient mechanism for active flagellar synchronization.
  • Cells can actively control flagellar coordination through modulating basal coupling and activity.
  • The developed ratio offers insights into experimentally inaccessible biological parameters.