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Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Integrating oral immunotherapy into clinical practice.

Stephanie A Leonard¹, Susan Laubach¹, Julie Wang²

¹Division of Pediatric Allergy & Immunology, University of California San Diego, Rady Children's Hospital San Diego, San Diego, Calif.

The Journal of Allergy and Clinical Immunology

|January 13, 2021

Summary

New food allergy treatments, like oral immunotherapy (OIT) for peanut allergy, are now available. Allergy offices must adapt practices to offer these intensive therapies, requiring careful patient selection and team readiness.

Keywords:

Oral immunotherapy epicutaneous immunotherapy food allergy treatment sublingual immunotherapy

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Area of Science:

Allergy and Immunology
Pharmacology

Background:

The FDA approved the first food allergy treatment, an oral immunotherapy (OIT) product for peanut allergy, in 2020.
A peanut epicutaneous immunotherapy patch is also under review, signaling a new era in food allergy management.

Purpose of the Study:

To guide allergy practices in adapting to the availability of new food allergy treatments, particularly OIT.
To outline essential considerations for implementing and managing OIT in an clinical setting.

Main Methods:

Review of clinical trial data and cohort experiences to identify suitable candidates for OIT.
Discussion of practical aspects including staffing, space, protocols, and team roles.
Examination of screening, dosing, monitoring, safety, and maintenance procedures for OIT.

Main Results:

OIT requires significant patient and family commitment and open communication with healthcare providers.
Identifying ideal OIT candidates remains an area for research, but existing data offers guidance.
Successful OIT implementation necessitates understanding scope of practice, adequate staffing, and robust safety protocols.

Conclusions:

Allergy offices must prepare for the integration of OIT and other emerging food allergy therapies.
Careful patient selection, comprehensive staff training, and established protocols are crucial for safe and effective OIT delivery.
Ongoing research into adjunct therapies will further enhance food allergy treatment options.