Related Experiment Video
Updated: Nov 21, 2025

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
COVID-19 Manifesting as Renal Allograft Dysfunction, Acute Pancreatitis, and Thrombotic Microangiopathy: A Case
Tiana Jespersen Nizamic1, Yihung Huang1, Muna Alnimri1
1Division of Nephrology, University of California, Davis School of Medicine, Sacramento, California.
Insights
This study reports the first case of thrombotic microangiopathy in a kidney transplant recipient with COVID-19. The patient recovered with supportive care, highlighting a rare but serious complication of the virus in transplant patients.
Area of Science:
- Nephrology
- Transplantation
- Infectious Diseases
Background:
- Coronavirus disease 2019 (COVID-19) presents significant morbidity and mortality globally.
- Kidney transplant recipients are a vulnerable population susceptible to severe COVID-19 complications.
- Acute kidney injury and coagulopathy are recognized, though not fully understood, complications of COVID-19.
Abstract:
Coronavirus disease 2019 (COVID-19) is associated with high morbidity and mortality worldwide in both the general population and kidney transplant recipients. Acute kidney injury is a known complication of COVID-19 and appears to most commonly manifest as acute tubular injury on renal biopsy. Coagulopathy associated with COVID-19 is a known but poorly understood complication that has been reported to cause thrombotic microangiopathy on rare occasions in native kidneys of patients with COVID-19. Here, we report the first case of biopsy-proven thrombotic microangiopathy in a kidney transplant recipient with COVID-19 who developed acute pancreatitis and clinical features of microangiopathic hemolytic anemia. The patient recovered with supportive care alone.
Related Concept Videos
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury II: Pathophysiology
Chronic Kidney Disease II: Clinical Manifestations
Kidney Transplant I: Introduction
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction

