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Related Experiment Videos

Extracorporeal shock wave lithotripsy and its effect on renal function.

B R Gilbert1, R A Riehle, E D Vaughan

  • 1Department of Surgery (Division of Urology), New York Hospital/Cornell University Medical Center, New York.

The Journal of Urology
|March 1, 1988
PubMed
Summary

Extracorporeal shock wave lithotripsy (ESWL) may cause temporary proteinuria but does not harm kidney function long-term. Kidney function improves after ESWL if stones caused obstruction.

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Area of Science:

  • Nephrology
  • Urology
  • Biomedical Engineering

Background:

  • Extracorporeal shock wave lithotripsy (ESWL) is a primary treatment for upper tract renal stones.
  • The long-term effects of ESWL on renal function remain unclear.

Purpose of the Study:

  • To evaluate the short-term and long-term effects of ESWL on renal function.
  • To assess changes in creatinine clearance, sodium excretion, protein excretion, and urine osmolality post-ESWL.

Main Methods:

  • Physiological parameters were measured before and after ESWL in 26 patients.
  • A follow-up study assessed patients with significant proteinuria for 3-6 months.

Main Results:

  • Transient nephrotic-range proteinuria occurred immediately after ESWL, resolving within 3-6 months.

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  • Glomerular filtration rate (GFR) did not change overall but increased in obstructed kidneys post-ESWL.
  • Renal concentrating and sodium-conserving abilities were maintained post-treatment.

    • Conclusions:

    • ESWL causes temporary proteinuria but does not impair long-term renal function.
    • ESWL can improve GFR in kidneys previously affected by stone obstruction.
    • Renal physiological functions remain intact after ESWL treatment.