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Management of Cardiac Sarcoidosis in 2020

Nisha Gilotra1, David Okada1, Apurva Sharma1

  • 1Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, US.

Arrhythmia & Electrophysiology Review
|January 13, 2021
PubMed

Insights

Cardiac sarcoidosis (CS) is an inflammatory condition affecting the heart, presenting with arrhythmias and heart failure. Advanced imaging aids diagnosis, while updated management focuses on immunosuppression and targeted therapies.

Area of Science:

  • Cardiology
  • Immunology
  • Pathology

Background:

  • Sarcoidosis is a multisystem inflammatory disease.
  • Cardiac involvement occurs in up to 25% of systemic sarcoidosis patients.
  • Cardiac sarcoidosis (CS) presents with diverse clinical manifestations.

Purpose of the Study:

  • To provide an update on the diagnosis and management of cardiac sarcoidosis.
  • To review clinical manifestations, diagnostic imaging, and therapeutic strategies for CS.
  • To identify knowledge gaps and future research directions in CS.

Main Methods:

  • Review of current literature on cardiac sarcoidosis diagnosis and management.
  • Emphasis on the role of advanced cardiac imaging in identifying CS.
  • Discussion of updated treatment protocols including immunosuppression and supportive therapies.

Main Results:

  • Diagnosis of CS is improving with advanced cardiac imaging.
  • Clinical manifestations include heart block, arrhythmias, and heart failure.
  • Corticosteroids are standard, with evolving roles for steroid-sparing agents.

Conclusions:

  • Early diagnosis and management of CS are crucial.
  • Multidisciplinary approach is essential for optimal patient outcomes.
  • Further research is needed to refine treatment strategies and address knowledge gaps.

Keywords:
Sarcoidarrhythmiascardiac sarcoidheart failureimmunosuppression

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