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Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential
Fabien Huet1,2, Jérémy Fauconnier2, Marion Legall2
1Department of Cardiology, Montpellier University Hospital, Montpellier, Occitanie, France.
Purpose:
To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI).
Materials & Methods:
Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion.
Results:
Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70).
Conclusion:
These results suggest promising protective pathway of colchicine after AMI.
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