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Updated: Nov 21, 2025
05:07
Characterizing Extracellular Vesicles from Biological Fluids
Published on: February 28, 2025
669
Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering
Fei Teng1, Martin Fussenegger1,2
1Department of Biosystems Science and Engineering ETH Zurich Mattenstrasse 26 Basel CH-4058 Switzerland.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 13, 2021
Summary
Extracellular vesicles (EVs) are nano-sized biological vesicles with low immunogenicity, making them promising for drug delivery. Bioengineering strategies are advancing their potential for clinical applications.
Area of Science:
- Biotechnology
- Nanomedicine
- Cell Biology
Background:
- Extracellular vesicles (EVs) are nano-sized, secreted vesicles containing diverse biomolecules.
- EVs possess low immunogenicity and can modify recipient cells.
- These properties make EVs attractive for next-generation drug delivery systems.
Purpose of the Study:
- To summarize recent advances in extracellular vesicle (EV) biology.
- To review emerging strategies in EV bioengineering.
- To discuss the clinical translation prospects and challenges of bioengineered EVs.
Main Methods:
- Literature review of recent advances in EV biology.
- Analysis of emerging EV bioengineering strategies.
- Discussion of clinical translation data and challenges.
Main Results:
- EVs are biocompatible nanovesicles carrying proteins, RNAs, DNAs, lipids, and metabolites.
- EVs' ability to transfer bioactive molecules and low immunogenicity are key for drug delivery.
- Bioengineering approaches are enhancing EV therapeutic potential.
Conclusions:
- Bioengineered EVs show significant promise for clinical drug delivery applications.
- Overcoming challenges in EV production, targeting, and regulation is crucial for translation.
- Continued research in EV biology and bioengineering will drive clinical advancements.
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