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Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation
Published on: July 27, 2022
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Complications during multiorgan retrieval and pancreas preservation
Daniel Casanova1, Gonzalo Gutierrez2, Monica Gonzalez Noriega2
1Department of Surgery, University Hospital Marques de Valdecilla, University Cantabria, Santander 39008, Cantabria, Spain. daniel.casanova@unican.es.
World Journal of Transplantation
|January 13, 2021
Summary
Pancreas transplantation faces complications, but advanced preservation techniques like normothermic machine perfusion (NECMO) improve organ viability. This enhances donor pool and transplant success rates for donors after cardiac arrest (DCD).
Area of Science:
- Transplantation immunology and surgery
- Organ preservation technologies
Background:
- Pancreas transplantation is susceptible to complications throughout donor selection, surgery, and post-operative immunosuppression.
- Organ viability hinges on meticulous pancreas retrieval and preservation, critical due to the gland's low-flow nature and susceptibility to ischemic injury and pancreatitis.
Purpose of the Study:
- To explore distinct retrieval and preservation strategies for donors after brain death (DBD) and donors after cardiac arrest (DCD).
- To highlight the role of novel preservation technologies in optimizing organ quality and expanding the donor pool.
Main Methods:
- Comparison of conventional cold preservation for DBD donors.
- Application of advanced hypothermic and normothermic machine perfusion (NECMO) for DCD donors.
Main Results:
- Normothermic machine perfusion (NECMO) shows promise in optimizing pancreas preservation for DCD transplantation.
- Advanced preservation techniques facilitate the use of organs previously deemed unsuitable, thereby increasing the donor pool.
Conclusions:
- Tailored organ preservation strategies are essential for mitigating complications in pancreas transplantation.
- Emerging technologies like NECMO significantly enhance organ viability and expand donor availability, particularly for DCD donors.
