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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Anticancer Natural Products with Collateral Sensitivity: A Review
Jiajun Qian1, Jiahua Cui1, Shaoshun Li2
1School of Environmental Science and Engineering, Shanghai Jiaotong University, China.
Background:
Multidrug resistance (MDR) is the resistance of cancer cells against a variety of currently used antineoplastic agents with diverse structural scaffolds and different anticancer mechanisms. It has been recognized as one of the major impediments to the successful treatment of cancer, leading to the metastasis and relapse of malignant diseases.
Introduction:
Collateral sensitivity (CS) is the characteristic of certain chemicals to kill the drugresistant sublines selectively over the parental cell lines from which the resistant cells were generated. The research and development of new drug candidates with collateral sensitivity will be an efficient approach to conquer multidrug resistance in cancer. We aim to provide an update on the discovery of natural products with collateral sensitivity.
Results And Conclusion:
The review focused on the characterized anticancer natural products and their derivatives with collateral sensitivity, their working mechanisms, and related structure-activity relationships, emphasizing recently identified CS compounds. According to their structural features, these MDR-targeting compounds were mainly classified into the following categories: flavonoids, terpenoids, stilbenes, alkaloids and quinones. The exploration of molecular mechanisms of collateral sensitivity and structural features of anticancer agents with collateral sensitivity provided an effective approach for the clinic treatment of MDR in cancer.
Insights
Natural products offer a promising strategy to overcome multidrug resistance (MDR) in cancer. Discovering compounds with collateral sensitivity (CS) selectively targets resistant cancer cells, aiding treatment and preventing relapse.
Area of Science:
- Natural product chemistry
- Cancer biology
- Pharmacology
Background:
- Multidrug resistance (MDR) is a significant challenge in cancer therapy, leading to treatment failure.
- Collateral sensitivity (CS) presents an opportunity, where compounds selectively kill drug-resistant cells.
Purpose of the Study:
- To review natural products and their derivatives exhibiting collateral sensitivity against cancer.
- To update on the discovery of novel compounds with CS properties.
Main Methods:
- Literature review of characterized anticancer natural products.
- Analysis of working mechanisms and structure-activity relationships (SAR) of CS compounds.
Main Results:
- Identified CS compounds are classified into flavonoids, terpenoids, stilbenes, alkaloids, and quinones.
- Detailed exploration of molecular mechanisms underlying CS and SAR.
Conclusions:
- Natural products with CS are effective in targeting multidrug-resistant cancer.
- Understanding CS mechanisms and compound structures aids in developing new cancer treatments.
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