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Anticancer Natural Products with Collateral Sensitivity: A Review
Jiajun Qian1, Jiahua Cui1, Shaoshun Li2
1School of Environmental Science and Engineering, Shanghai Jiaotong University, China.
Mini Reviews in Medicinal Chemistry
|January 13, 2021
Summary
Natural products offer a promising strategy to overcome multidrug resistance (MDR) in cancer. Discovering compounds with collateral sensitivity (CS) selectively targets resistant cancer cells, aiding treatment and preventing relapse.
Area of Science:
- Natural product chemistry
- Cancer biology
- Pharmacology
Background:
- Multidrug resistance (MDR) is a significant challenge in cancer therapy, leading to treatment failure.
- Collateral sensitivity (CS) presents an opportunity, where compounds selectively kill drug-resistant cells.
Purpose of the Study:
- To review natural products and their derivatives exhibiting collateral sensitivity against cancer.
- To update on the discovery of novel compounds with CS properties.
Main Methods:
- Literature review of characterized anticancer natural products.
- Analysis of working mechanisms and structure-activity relationships (SAR) of CS compounds.
Main Results:
- Identified CS compounds are classified into flavonoids, terpenoids, stilbenes, alkaloids, and quinones.
- Detailed exploration of molecular mechanisms underlying CS and SAR.
Conclusions:
- Natural products with CS are effective in targeting multidrug-resistant cancer.
- Understanding CS mechanisms and compound structures aids in developing new cancer treatments.
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