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Updated: Nov 21, 2025

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Significant Operational Improvements with Implementation of Next Generation Laboratory Automation.

Milenko J Tanasijevic^1,2, Stacy E F Melanson^1,2, Nicole V Tolan^1,2

¹Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Laboratory Medicine

|January 13, 2021

Summary

Implementing next generation laboratory automation significantly reduced turnaround time (TAT) for chemistry and coagulation tests. This advanced automation offers benefits for laboratories seeking efficient specimen processing and archival.

Keywords:

add-on testing automation chemistry systems clinical chemistry preanalytical line turnaround time

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Area of Science:

Clinical Chemistry
Hematology
Laboratory Automation

Background:

The integration of advanced automation in clinical laboratories is crucial for improving efficiency and reducing errors.
Next-generation preanalytical systems offer enhanced capabilities for specimen handling and archival.

Purpose of the Study:

To evaluate the advantages and difficulties associated with implementing next-generation chemistry and coagulation automation.
To assess the impact of a new automated preanalytical system on turnaround times.

Main Methods:

Replacement of the Roche modular preanalytic system with the Roche 8100 preanalytical line and Stago STA R Max analyzers.
Inclusion of automated specimen archival and retrieval buffers (AOBs).
Measurement of turnaround time (TAT) for chemistry, coagulation, and add-on tests before, during, and after implementation.

Main Results:

Successful implementation of the automated system within a 17-month period.
Significant reductions in TAT for chemistry (P <.005), coagulation (P <.001), and add-on tests (P <.005).
Identified challenges including barcode errors, mechanical issues, and workflow disruptions.

Conclusions:

Next-generation laboratory automation leads to significantly shorter and more consistent TAT, especially for add-on tests.
The implemented approach provides a valuable model for other laboratories undergoing automation implementation and configuration.