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Inspiratory Muscle Weakness is Related to Poor Short-Term Outcomes for Heart Transplantation
Isis Begot1, Walter J Gomes1,2, Isadora S Rocco1
1Cardiology Postgraduate Program, Federal University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil.
Brazilian Journal of Cardiovascular Surgery
|January 13, 2021
Summary
Preoperative inspiratory muscle strength is a key predictor of outcomes after heart transplantation (HT). Weakness in these muscles is linked to longer mechanical ventilation (MV) and intensive care unit (ICU) stays post-surgery.
Area of Science:
- Cardiology
- Pulmonology
- Transplantation Medicine
Background:
- Heart transplantation (HT) requires effective rehabilitation strategies for optimal patient outcomes.
- Identifying preoperative risk factors is crucial for predicting the postoperative clinical course in HT recipients.
Purpose of the Study:
- To determine patient-related preoperative risk factors that may adversely affect the postoperative clinical course of patients undergoing heart transplantation.
Main Methods:
- Evaluated 21 heart failure patients undergoing HT.
- Assessed preoperative respiratory muscle strength and functional capacity.
- Recorded postoperative mechanical ventilation (MV) time, reintubation rate, and intensive care unit (ICU) length of stay.
Main Results:
- Inspiratory muscle strength strongly correlated with MV time (r=-0.61 to -0.70, P<0.001).
- Maximal inspiratory pressure (MIP) was significantly associated with ICU length of stay (r=-0.58 to -0.68, P<0.007).
- Respiratory muscle weakness predicted prolonged MV, reintubation, and delayed ICU stay.
Conclusions:
- Impaired preoperative maximal inspiratory pressure (MIP) is linked to poorer short-term outcomes after HT.
- Inspiratory muscle strength serves as a vital preoperative clinical marker for heart transplant candidates.
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