Related Experiment Video

Updated: Nov 21, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.2K

Iron Sucrose: A Double-Edged Sword in High Phosphate Media-Induced Vascular Calcification

Ping Wang1, Chengkun Guo1, Hui Pan1

  • 1Nephrology Department, The First People's Hospital of Jingmen, Jingmen, 448000, Hubei, China.

Calcified Tissue International
|January 13, 2021
PubMed

Insights

Iron sucrose (IS) can alleviate vascular calcification (VC) in high phosphate conditions but may cause iron overload at high concentrations. Further clinical studies are needed to determine optimal IS blood levels for patients with hyperphosphatemia.

Area of Science:

  • Nephrology
  • Biochemistry
  • Cardiovascular Medicine

Background:

  • Vascular calcification (VC) is prevalent in chronic kidney disease (CKD) patients.
  • Hyperphosphatemia is a key driver of VC in CKD.
  • The role of intravenous iron sucrose (IS) in VC is debated.

Purpose of the Study:

  • To investigate the dual effects of IS on high phosphate-induced VC.
  • To elucidate the mechanisms underlying IS interaction with VC.

Main Methods:

  • Ex vivo culture of rat aortic rings with varying phosphate and IS concentrations.
  • Measurement of calcium and iron deposition.
  • Assessment of oxidative injury and gene expression.

Main Results:

  • IS demonstrated a dose-dependent alleviation of VC.
  • High IS concentrations led to significant iron deposition in vasculature.
  • Oxidative stress markers and phenotypic gene expression were altered.

Conclusions:

  • IS acts as a double-edged sword in high phosphate-induced VC.
  • IS may be beneficial for VC prevention in hyperphosphatemic, iron-deficient CKD patients.
  • Clinical research is required to establish safe and effective IS blood concentrations.

Keywords:
HyperphosphatemiaIron sucroseOxidative injuryType III sodium-dependent phosphate cotransporter-1Vascular calcification

More Related Videos

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.9K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.9K

Related Concept Videos

Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
897
Introduction to Electrolytes01:33

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
14.5K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.3K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.5K
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
9.7K
Factors Affecting Solubility04:01

Factors Affecting Solubility

Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
35.7K