Long-term survival with multiple metastasectomies for pulmonary osteosarcoma: a case report

Area of Science:

• Oncology
• Surgical Oncology
• Pulmonary Medicine

Background:

• Osteosarcoma commonly metastasizes to the lungs, necessitating aggressive treatment strategies.
• Repeat pulmonary metastasectomy (PM) is a recognized approach to improve prognosis in patients with pulmonary metastases.
• Limited data exists on outcomes following more than six repeat PMs for osteosarcoma.

Purpose of the Study:

• To report the long-term survival of a patient with recurrent pulmonary osteosarcoma metastases.
• To emphasize the role of extensive surgical resection and multidisciplinary treatment in managing advanced metastatic osteosarcoma.

Main Methods:

• A case study of a 28-year-old female patient with right tibial osteosarcoma and subsequent pulmonary metastases.
• Initial extensive resection and adjuvant chemotherapy followed by multiple pulmonary metastasectomies (PMs) for over 250 tumors.
• Inclusion of other treatments for deep metastatic lesions.

Main Results:

• The patient underwent extensive surgical resection of bilateral pulmonary metastases.
• Over 250 tumors were removed across multiple PM procedures.
• The patient survived for 24 years after the primary surgery, despite the advanced metastatic disease.

Conclusions:

• Multidisciplinary treatment, with a focus on multiple pulmonary metastasectomies, can lead to long-term survival in select osteosarcoma patients.
• This case underscores the potential benefit of aggressive surgical management for recurrent pulmonary metastases.