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Updated: Nov 21, 2025
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
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Drug-eluting stent thrombosis: current and future perspectives
Shoichi Kuramitsu1, Shinjo Sonoda2, Kenji Ando3
1Department of Cardiology, Kokura Memorial Hospital, 3-2-1 Asano, Kokurakita-ku, Kitakyushu, 802-8555, Japan. kuramitsu@circulation.jp.
Cardiovascular Intervention and Therapeutics
|January 13, 2021
Summary
Drug-eluting stents (DES) improved percutaneous coronary intervention, but first-generation DES (G1-DES) raised stent thrombosis (ST) risks. Second-generation DES (G2-DES) reduced ST, but it still occurs, necessitating review of its causes and prevention.
Area of Science:
- Interventional Cardiology
- Biomaterials Science
Background:
- Percutaneous coronary intervention (PCI) has advanced significantly over 40 years.
- Drug-eluting stents (DES) revolutionized PCI by reducing restenosis and revascularization.
- First-generation DES (G1-DES) introduced concerns regarding stent thrombosis (ST).
Purpose of the Study:
- To review the pathophysiology, risk factors, and outcomes of ST after DES implantation.
- To discuss current management and prevention strategies for ST.
- To highlight the evolution of DES technology in mitigating ST risks.
Main Methods:
- Literature review of studies on DES implantation and stent thrombosis.
- Analysis of clinical outcomes comparing G1-DES and G2-DES.
- Synthesis of data on ST pathophysiology, risk factors, and management.
Main Results:
- G1-DES significantly reduced restenosis but increased ST incidence.
- G2-DES demonstrated improved safety profiles with reduced late thrombotic events.
- ST remains a concern even with G2-DES, underscoring the need for ongoing vigilance.
Conclusions:
- DES technology has progressed, with G2-DES offering improved safety over G1-DES.
- Understanding ST pathophysiology and risk factors is crucial for effective prevention.
- Comprehensive management strategies are essential to minimize ST complications post-DES implantation.
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