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2° Amines to N-Nitrosamines: Reaction with NaNO2

2° Amines to N-Nitrosamines: Reaction with NaNO₂

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.

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Updated: Nov 21, 2025

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

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Melflufen: A Next-Generation Nitrogen Mustard

Sarah A Holstein¹, Jens Hillengass², Philip L McCarthy²

¹Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

|January 13, 2021

Summary

No abstract available in PubMed .

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