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Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Microbiome and ischemic stroke: A systematic review.

Yee Teng Lee¹, Nor Ismaliza Mohd Ismail¹, Loo Keat Wei¹

¹Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, Perak, Malaysia.

|January 13, 2021

Summary

This systematic review explores the link between the human microbiome and ischemic stroke. Findings suggest aging and inflammation influence microbial composition, impacting stroke risk and outcomes.

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Published on: October 15, 2019

Area of Science:

Neurology
Microbiology
Immunology

Background:

Ischemic stroke is a leading cause of death globally.
The connection between the human microbiome and ischemic stroke was previously unclear.

Purpose of the Study:

To systematically review the existing literature on the relationship between the human microbiome and ischemic stroke.

Main Methods:

A systematic review of articles was conducted.
Data was extracted from eligible studies published up to October 22, 2020.

Main Results:

Eighteen studies were included, indicating aging, inflammation, and microbial composition influence ischemic stroke.
Microbiota-derived short-chain fatty acids and trimethylamine N-oxide play key roles.
Phyla Firmicutes and Bacteroidetes impact post-stroke outcomes.

Conclusions:

This is the first systematic review on the microbiome-ischemic stroke relationship.
Aging and inflammation drive microbial changes that increase ischemic stroke susceptibility.