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Related Concept Videos

Structures of Solids02:22

Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
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Related Experiment Video

Updated: Nov 21, 2025

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
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Liquid-like Solids Support Cells in 3D.

Tapomoy Bhattacharjee1, Carmen J Gil2, Samantha L Marshall1

  • 1Department of Mechanical & Aerospace Engineering, 571 Gale Lemerand Drive, University of Florida, Gainesville, Florida 32611, United States.

ACS Biomaterials Science & Engineering
|January 14, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel 3D bioprinting platform using a unique liquid-like solid (LLS) material. This integrated system supports 3D cell culture, experimentation, and assay development, advancing tissue engineering and cell biology research.

Keywords:
3D printingbioprintingbiowritingcancerhigh throughput screeningthree-dimensional cell culturetumor engineering

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Area of Science:

  • Biotechnology
  • Materials Science
  • Cell Biology

Background:

  • Tissue engineering research extensively uses 3D tissue culture and 3D printing.
  • Transition to 3D cell culture is hindered by the lack of 3D tools and the prevalence of 2D methods.
  • 3D bioprinting advancements offer potential solutions for broader 3D culture adoption.

Purpose of the Study:

  • To investigate an integrated 3D bioprinting platform for multicellular structures.
  • To utilize the platform for simultaneous 3D cell culture, experimentation, and assay development.
  • To employ a novel liquid-like solid (LLS) material with unique rheological properties.

Main Methods:

  • Utilized a liquid-like solid (LLS) material composed of granular-scale microgels.
  • Demonstrated LLS material's ability to fluidize under stress and solidify upon stress removal.
  • Employed the platform for 3D printing multicellular structures and subsequent cell culture and assays.

Main Results:

  • Assessed viability of 11 different cell types within the LLS material.
  • Successfully 3D printed diverse multicellular structures using multiple cell types.
  • Explored LLS material's transport properties for molecular time-release assays and nutrient delivery.

Conclusions:

  • The integrated 3D bioprinting platform using LLS material enables versatile applications in cell culture and experimentation.
  • LLS material's properties support 3D printing, cell growth, and molecular diffusion for assays.
  • This technology has the potential to facilitate broader adoption of 3D cell culture techniques in biological research.