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Human Induced Pluripotent Stem Cell Derived Neural Stem Cell Survival and Neural Differentiation on Polyethylene
Hyun Ju Lim1, Zara Khan1, Thomas S Wilems1
1The Vivian L. Smith Department of Neurosurgery and Center for Stem Cells and Regenerative Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, 1825 Pressler, Houston, Texas 77030, United States.
Abstract:
Although preclinical models of spinal cord injury have shown that matrix inclusion in stem cell therapy leads to greater neurological improvements than that including cells alone, there has been insufficient matrix optimization for human cells. N-Cadherin influences the development and maintenance of neural tissue, but the effects of N-cadherin derived peptide His-Ala-Val-Asp-Ile (HAVDI) on the survival, neurite extension, and expression of neural differentiation markers in human induced pluripotent stem cell derived neural stems (hNSC) have not been widely examined. Using polyethylene glycol hydrogels containing a continuous gradient of HAVDI, this study identifies concentration dependent effects on hNSC survival and neural differentiation.
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