Simultaneously performed combined 24-2 and 10-2 visual field tests in glaucoma.

Area of Science:

• Ophthalmology
• Neuroscience

Background:

• Glaucomatous visual field (VF) defects present diverse patterns.
• Standard visual field testing (24-2 or 10-2) may not capture all defect types.
• Assessing the structure-function relationship is crucial for understanding glaucoma progression.

Purpose of the Study:

• To evaluate the diagnostic performance of combined 24-2 and 10-2 visual field perimetry.
• To compare the structure-function correlation of combined versus separate perimetry methods.
• To investigate the utility of integrated perimetry for detecting specific glaucomatous VF defects.

Main Methods:

• A custom combined Humphrey visual field test pattern was developed.
• Glaucoma patients with specific VF defects (nasal step, paracentral scotoma) were recruited.
• Structure-function relationships were analyzed using peripapillary retinal nerve fiber layer (RNFL) thickness and ganglion cell-inner plexiform layer (GCIPL) thickness.

Main Results:

• Combined 24-2 and 10-2 perimetry showed superior structure-function correlation in certain glaucoma types compared to individual tests.
• The combined VF test demonstrated better correlation with GCIPL thickness in inferotemporal/inferonasal areas than the 24-2 test alone.
• Simultaneous 24-2 and 10-2 testing yielded improved topographic structure-function relationships in specific sectors.

Conclusions:

• Integrated 24-2 and 10-2 visual field testing enhances the detection and characterization of glaucomatous visual field defects.
• Combined perimetry offers a more comprehensive assessment of the structure-function relationship in glaucoma.
• This approach may improve diagnostic accuracy and patient management in glaucoma care.