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Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study.

Danni Li1, Aniqa B Alam2, Fang Yu3

  • 1Department of Lab Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, MMC 609, Minneapolis, MN, 55455, USA. dannili@umn.edu.

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Summary
This summary is machine-generated.

Long-chain sphingomyelin 41:1 (SM 41:1) was linked to better physical function in older adults. This specific sphingomyelin was cross-sectionally associated with improved performance on physical function tests and lower self-reported disability.

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Area of Science:

  • Biochemistry
  • Gerontology
  • Neuroscience

Background:

  • Long-chain sphingomyelins (SMs) are crucial for myelin sheath stability, impacting physical function.
  • Understanding the role of specific SMs and ceramides in aging is important for maintaining mobility.

Purpose of the Study:

  • To investigate the association between long-chain sphingomyelins (SMs) and ceramides and physical function.
  • To examine both cross-sectional and longitudinal relationships in older adults.

Main Methods:

  • Plasma concentrations of SM (41:1), SM (41:2), SM (43:1), Cer (41:1), and Cer (43:1) were measured.
  • Physical function was assessed using grip strength, Short Physical Performance Battery (SPPB), 4-m walking speed, and self-reported disability.
  • Multivariable regression analyses were performed, controlling for confounders.

Main Results:

  • Plasma SM 41:1 showed a positive cross-sectional association with SPPB score and 4-m walking speed.
  • Higher SM 41:1 concentrations were negatively associated with self-reported disability.
  • No significant associations were found for longitudinal changes in physical function or mobility incidence.

Conclusions:

  • Plasma long-chain SM 41:1 is cross-sectionally associated with better physical function in older adults.
  • These findings suggest a potential role for SM 41:1 in maintaining physical performance in aging populations.