Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory.

Science advances·2026
Same author

Enhanced RHO-ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell carcinoma.

Cytoskeleton (Hoboken, N.J.)·2024
Same author

Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response.

Science advances·2024
Same author

An orthotopic syngeneic mouse model of bortezomib-resistant multiple myeloma.

British journal of haematology·2023
Same author

Basonuclin-2 regulates extracellular matrix production and degradation.

Life science alliance·2023
Same author

Bevacizumab-Induced Hypertension in Glioblastoma Patients and Its Potential as a Modulator of Treatment Response.

Hypertension (Dallas, Tex. : 1979)·2023

Related Experiment Video

Updated: Nov 21, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.6K

Tumour-directed microenvironment remodelling at a glance.

Sarah T Boyle1, M Zahied Johan1, Michael S Samuel2,3

  • 1Centre for Cancer Biology, An Alliance between SA Pathology and the University of South Australia, Adelaide, SA 5001, Australia.

Journal of Cell Science
|January 14, 2021
PubMed
Summary
This summary is machine-generated.

Tumors hijack the normal tissue microenvironment, altering its biochemistry and biophysics to promote growth. Targeting these tumor-microenvironment interactions offers a promising strategy for novel anti-cancer therapies.

Keywords:
CancerExtracellular matrixMechanobiologyMicroenvironmentSignalling

More Related Videos

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.1K
Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

11.8K

Related Experiment Videos

Last Updated: Nov 21, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.6K
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.1K
Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

11.8K

Area of Science:

  • Cell Biology
  • Cancer Biology
  • Biophysics

Background:

  • The tissue microenvironment normally supports parenchymal cell function.
  • Tumor cells exhibit altered behavior, making the microenvironment initially hostile.
  • Tumors must remodel the microenvironment to facilitate growth and metastasis.

Purpose of the Study:

  • To outline key processes by which epithelial tumors establish a tumor microenvironment.
  • To discuss the challenges and vulnerabilities associated with tumor control of the microenvironment.
  • To review how tumor-microenvironment interactions inform novel anti-cancer therapies.

Main Methods:

  • Review of key processes in tumor microenvironment establishment.
  • Analysis of tumor cell interactions with genetically normal stromal cells.
  • Synthesis of current research on targeting tumor-microenvironment interactions.

Main Results:

  • Epithelial tumors actively co-opt and remodel the microenvironment.
  • Tumor-induced modifications involve biochemical and biophysical changes.
  • The microenvironment's cellular components present both challenges and vulnerabilities for tumors.

Conclusions:

  • Understanding tumor-driven microenvironment remodeling is crucial.
  • Targeting tumor-microenvironment interactions represents a key strategy for developing new cancer treatments.
  • Novel anti-cancer therapies can emerge from insights into these complex interactions.