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Updated: Nov 21, 2025
Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
3D printing of robust and biocompatible poly(ethylene glycol)diacrylate/nano-hydroxyapatite composites via continuous
Xueyong Deng1, Bingxue Huang1, Rui Hu1
1State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute at Sichuan University, Chengdu 610065, China. weizhang@scu.edu.cn.
Abstract:
Three-dimensional (3D) printing technology with satisfactory speed and accuracy has been a powerful force in biomaterial processing. Early studies on 3D printing of biomaterials mainly focused on their biocompatibility and cellular viability while rarely attempted to produce robust specimens. Nonetheless, the biomedical applications of polymers can be severely limited by their inherently weak mechanical properties particularly in bone tissue engineering. In this study, continuous liquid interface production (CLIP) is applied to construct 3D objects of nano-hydroxyapatite (n-HA) filled polymeric biomaterials with complex architectures. Notably, the bioactive and osteoconductive n-HA endows the 3D prints of poly(ethyleneglycol)diacrylate (PEGDA) composites with a high compression strength of 6.5 ± 1.4 MPa, about 342% improvement over neat PEGDA. This work demonstrates the first successful attempt on CLIP 3D printing of n-HA nanocomposites, providing a feasible, cost-effective and patient-specific solution to various fields in the biomedical industry.
